Senior Scientist RNA Machine Learning, Vaccines

Description: Position Overview:In the race for the future of health ? The Sanofi mRNA Center of ExcellenceAt Sanofi, we believe in a world in which no one suffers or dies from vaccine-preventable diseases. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines for more people faster than before. That?s why we?re looking for bold, optimistic world-changers to join the team at our mRNA Center of Excellence. We?re investing ?400m a year into the new Center, hiring a team of 400 dedicated employees for it and using it as the foundation to implement integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.Bring your ambition and optimism for the future to Sanofi. Join us.Sanofi Pasteur, Vaccine R&D is strategically developing and deploying state-of-the-art digital strategies/tools to meet Sanofi Pasteur's mission to become the disruptive market leader in vaccines. Vaccine R&D seeks entrepreneurial and forward-thinking individuals to drive the development of Artificial Intelligence (AI) / Machine Learning (ML) / Deep Learning (DL) solutions to improve efficiency and effectiveness across research and development.S/he will have deep knowledge and experience in both RNA Biology/Biophysics/Biochemistry and bioinformatics/data science/machine learning and the ability to rapidly transform theory to actionable prototype. S/he will be responsible for designing, prototyping and validating computational solutions to diverse scientific challenges in the fields of mRNA vaccines and therapeutics. S/he will have a high degree of proficiency in Python/R, machine learning and deep learning libraries, bioinformatics tools and cloud computing.S/he will be ready to hit the ground running in a fast-paced environment that rewards personal initiative, collaboration, and scientific excellence.Key Responsibilities:Collaborates with stakeholders and other group experts in the development and execution of the scientific strategy and technical solutions to develop best-in-class mRNA vaccines and therapeuticsActs as a scientific expert and partner in the fields of RNA biology/biochemistry/biophysics and AI/MLLead efforts to design and optimize mRNA vaccines, optimize formulations, predict performanceDesign and assess studies to evaluate the performance of mRNA vaccines and therapeutics. Translate experimental learnings into the development and refinement of computational models for design, optimization, selection and formulation of mRNA vaccinesDevelops and evaluates computational and statistical methods for data analysisDevelops, deploys, and assesses the results of at-scale models at varying levels of model granularity encompassing heterogeneous preclinical and clinical dataEmploys machine learning methods such as deep learning, neural networks, reinforcement learning, graphical and generative models to deconvolve high dimensional experimental and in silico modeling resultsMaintains a well-documented, reusable codebase, and traceable model historyGenerates IP and participates in the drafting of patent filingsBasic Qualifications:Advanced degree in computational biology/molecular biology (RNA) with expertise in machine learning or an advanced degree in computational sciences, machine learning or other technical fields with expertise in RNA biologyDeep knowledge and experience in RNA biology/biophysics/biochemistry (structure, function, engineering)High proficiency in machine learning (Deep Learning, Embeddings, Reinforcement and Transfer Learning) and algorithmic analysis of dataDemonstrated record of transforming algorithms/theory into practical applications delivering robust models that are high performance, interpretable and actionable.A creative problem solver, skilled in divergent thinking and turning complex data into actionable insights and knowledgeExcellent communication, scientific writing and presentation skills. Ability to develop and present results as visually appealing and understandable storiesUnderstanding of drug/vaccine discovery and development processes is a plus